Controlling complexity: the clinical relevance of mouse complex genetics

Eur J Hum Genet. 2013 Nov;21(11):1191-6. doi: 10.1038/ejhg.2013.79. Epub 2013 May 1.


Experimental animal models are essential to obtain basic knowledge of the underlying biological mechanisms in human diseases. Here, we review major contributions to biomedical research and discoveries that were obtained in the mouse model by using forward genetics approaches and that provided key insights into the biology of human diseases and paved the way for the development of novel therapeutic approaches.

Publication types

  • Review

MeSH terms

  • Animals
  • Biomedical Research
  • Humans
  • Mice
  • Models, Animal*
  • Reverse Genetics