Need to quickly excrete K(+)? Turn off NCC

Kidney Int. 2013 May;83(5):779-82. doi: 10.1038/ki.2012.468.


Renal K(+) excretion is increased rapidly following dietary K(+) intake, but the underlying molecular mechanisms are largely unknown. Sorensen and colleagues show that K(+) intake in mice provoked rapid and near-complete dephosphorylation of the renal distal convoluted tubule NaCl cotransporter, temporally associated with increases in both Na(+) and K(+) excretion. This response was independent of aldosterone and may be a crucial component of the acute homeostatic adaptation of the kidney to K(+) intake.

Publication types

  • Comment

MeSH terms

  • Animals
  • Female
  • Kidney / metabolism*
  • Male
  • Potassium, Dietary / blood*
  • Receptors, Drug / metabolism*
  • Solute Carrier Family 12, Member 3
  • Symporters / metabolism*


  • Potassium, Dietary
  • Receptors, Drug
  • Slc12a3 protein, mouse
  • Solute Carrier Family 12, Member 3
  • Symporters