Vitamin K: key vitamin in controlling vascular calcification in chronic kidney disease

Kidney Int. 2013 May;83(5):782-4. doi: 10.1038/ki.2013.26.

Abstract

Vascular calcification has emerged as an independent risk factor for cardiovascular morbidity and mortality, especially in chronic kidney disease. Deficiencies in calcium-regulatory proteins directly relate to development of calcifications. McCabe and colleagues report that vitamin K is a key regulator of vascular calcification, via carboxylation of vitamin K-dependent proteins such as matrix Gla protein. Knowledge about vitamin K status may propel therapeutic strategies to prevent and treat vascular calcification with high vitamin K supplementation.

Publication types

  • Comment

MeSH terms

  • Animals
  • Anticoagulants / toxicity*
  • Arteries / drug effects*
  • Dietary Supplements*
  • Male
  • Renal Insufficiency, Chronic / drug therapy*
  • Vascular Calcification / chemically induced*
  • Vascular Calcification / prevention & control*
  • Vitamin K 1 / pharmacology*
  • Warfarin / toxicity*

Substances

  • Anticoagulants
  • Warfarin
  • Vitamin K 1