Treadmill exercise elevates striatal dopamine D2 receptor binding potential in patients with early Parkinson's disease

Neuroreport. 2013 Jul 10;24(10):509-14. doi: 10.1097/WNR.0b013e328361dc13.


We have previously demonstrated changes in dopaminergic neurotransmission after intensive exercise in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse model of Parkinson's disease (PD), including an increase in the dopamine D2 receptor (DA-D2R), using noninvasive PET imaging with the radioligand [18F]fallypride. The purpose of this feasibility and translational study was to examine whether intensive exercise leads to similar alterations in DA-D2R expression using PET imaging with [18F]fallypride in individuals with early-stage PD. In this pilot study, four patients with early-stage PD were randomized to receive intensive exercise (treadmill training sessions three times/week for 8 weeks) or no exercise. Two healthy age-matched individuals participated in treadmill training. Alterations in the DA-D2R binding potential (BP) as a marker for receptor expression were determined using PET imaging with [18F]fallypride. Turning performance in the patients with PD as a measure of postural control and the Unified Parkinson's Disease Rating Scale scores pre-exercise and postexercise were determined. Our data showed an exercise-induced increase in [18F]fallypride BP as well as improved postural control in patients with PD who exercised. Changes in DA-D2R BP were not observed in patients with PD who did not exercise. These results suggest that exercise can lead to neuroplasticity in dopaminergic signaling and contribute to improved function that may be task specific (postural control) in early-stage PD.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzamides
  • Biomechanical Phenomena
  • Brain / pathology
  • Exercise Therapy*
  • Female
  • Gait / physiology
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Neostriatum / diagnostic imaging
  • Neostriatum / metabolism*
  • Neostriatum / pathology
  • Neuronal Plasticity / physiology
  • Parkinson Disease / diagnostic imaging
  • Parkinson Disease / metabolism*
  • Parkinson Disease / therapy*
  • Pilot Projects
  • Positron-Emission Tomography
  • Posture / physiology
  • Psychomotor Performance / physiology
  • Pyrrolidines
  • Radiopharmaceuticals
  • Receptors, Dopamine D2 / metabolism*


  • Benzamides
  • N-((1-allyl-2-pyrrolidinyl)methyl)-5-(3-fluoropropyl)-2,3-dimethoxybenzamide
  • Pyrrolidines
  • Radiopharmaceuticals
  • Receptors, Dopamine D2