Gap junction remodeling in skin repair following wounding and disease

Physiology (Bethesda). 2013 May;28(3):190-8. doi: 10.1152/physiol.00058.2012.

Abstract

In the present review, we provide an overview of connexin expression during skin development and remodeling in wound healing, and reflect on how loss- or gain-of-function connexin mutations may change cellular phenotypes and lead to diseases of the skin. We also consider the therapeutic value of targeting connexins in wound healing.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Cell Movement
  • Cell Proliferation
  • Connexins / genetics
  • Connexins / metabolism*
  • Gap Junctions / metabolism*
  • Gap Junctions / pathology
  • Genetic Predisposition to Disease
  • Humans
  • Mutation
  • Phenotype
  • Signal Transduction
  • Skin / growth & development
  • Skin / injuries
  • Skin / metabolism*
  • Skin / pathology
  • Skin Diseases / genetics
  • Skin Diseases / metabolism*
  • Skin Diseases / pathology
  • Wound Healing*

Substances

  • Connexins