Coronary aneurysms in infants and young children with acute febrile mucocutaneous lymph node syndrome

J Pediatr. 1975 Jun;86(6):892-8. doi: 10.1016/s0022-3476(75)80220-4.


In 1967, Kawasaki, in Japan, first described a new syndrome affecting infants and young children-an acute, febrile illness with mucocutaneous involvement associated with swelling of cervical lymph nodes. The prognosis is usually good but recently it has become evident that 1-2 percent of the patients die suddenly from acute heart failure. Infantile polyarteritis (nodosa-like arteritis) accompained by coronary aneurysm and thrombosis has been noted in postmortem examinations. Twenty patients surviving the illness were examined by coronary angiography; 12 of the 20 had abnormal coronary angiograms; seven patients had coronary aneurysms. Complete regression of the coronary aneurysms was proved in two patients at subsequent angiography. One patient developed mitral regurgitation as a result of papillary muscle dysfunction. One had a coronary aneurysm without symptoms two years after the onset of illness.

MeSH terms

  • Acute Disease
  • Aneurysm / diagnosis
  • Aneurysm / etiology*
  • Angiocardiography
  • Child
  • Child, Preschool
  • Coronary Disease / diagnosis
  • Coronary Disease / etiology*
  • Coronary Disease / prevention & control
  • Electrocardiography
  • Female
  • Fever
  • Humans
  • Infant
  • Lymph Nodes / physiopathology
  • Lymphatic Diseases / complications*
  • Lymphatic Diseases / mortality
  • Male
  • Mucous Membrane / physiopathology
  • Phonocardiography
  • Polyarteritis Nodosa / etiology*
  • Skin Manifestations / physiopathology