Immature and mature dengue serotype 1 virus structures provide insight into the maturation process

J Virol. 2013 Jul;87(13):7700-7. doi: 10.1128/JVI.00197-13. Epub 2013 May 1.


Dengue virus is a major human pathogen that has four serotypes (DENV1 to -4). Here we report the cryoelectron microscopy (cryo-EM) structures of immature and mature DENV1 at 6- and 4.5-Å resolution, respectively. The subnanometer-resolution maps allow accurate placement of all of the surface proteins. Although the immature and mature viruses showed vastly different surface protein organizations, the envelope protein transmembrane (E-TM) regions remain in similar positions. The pivotal role of the E-TM regions leads to the identification of the start and end positions of all surface proteins during maturation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cryoelectron Microscopy
  • Dengue Virus / genetics*
  • Dengue Virus / growth & development*
  • Dengue Virus / ultrastructure*
  • Models, Molecular*
  • Protein Conformation*
  • Serotyping
  • Viral Proteins / chemistry
  • Viral Proteins / metabolism*


  • Viral Proteins