Mechanism of Senescence of Red Blood Cells

Acta Biol Med Ger. 1977;36(5-6):831-6.

Abstract

An integral hypothesis is submitted on the interaction of endogenous and exogenous factors in the mechanism of senescence of erythrocytes and on their selective phagocytosis by autologous macrophages. A method that allows quantitative determination and preparative yield of senescent erythrocytes is proposed.

MeSH terms

  • Adenosine Triphosphate / metabolism
  • Calcium / metabolism
  • Cell Separation
  • Diphosphoglyceric Acids / metabolism
  • Erythrocyte Aging*
  • Erythrocyte Membrane / physiology
  • Erythrocytes / metabolism
  • Hemagglutination
  • Hemoglobins / metabolism
  • Humans
  • Magnesium / metabolism
  • NAD / metabolism
  • NADP / metabolism
  • Phagocytosis
  • Sialic Acids / metabolism

Substances

  • Diphosphoglyceric Acids
  • Hemoglobins
  • Sialic Acids
  • NAD
  • NADP
  • Adenosine Triphosphate
  • Magnesium
  • Calcium