Two new highly oxygenated and rearranged limonoids from Phyllanthus cochinchinensis

Org Lett. 2013 May 17;15(10):2414-7. doi: 10.1021/ol400875n. Epub 2013 May 2.

Abstract

A new 6/6/5/6-fused limonoid, phyllanthoid A (1), possessing both 19/30 and 19/29 oxygen bridges was isolated from Phyllanthus cochinchinensis (Euphorbiaceae), together with a new related limonoid, phyllanthoid B (2). Their structures were determined by spectroscopic analysis and single-crystal X-ray diffraction in the case of 1. Compound 1 displayed moderate antifeedant against the generalist plant-feeding insect Spodoptera exigua and cytotoxicity against the MCF-7 cell line.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Crystallography, X-Ray
  • Feeding Behavior / drug effects*
  • Humans
  • Larva
  • Limonins / chemistry*
  • Limonins / isolation & purification
  • Limonins / pharmacology
  • MCF-7 Cells
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Phyllanthus / chemistry*
  • Plant Extracts / chemistry*
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology

Substances

  • Limonins
  • Plant Extracts
  • phyllanthoid A
  • phyllanthoid B