Host and viral factors affecting clinical performance of a rapid diagnostic test for respiratory syncytial virus in hospitalized children

J Pediatr. 2013 Sep;163(3):911-3. doi: 10.1016/j.jpeds.2013.03.067. Epub 2013 Apr 30.


Respiratory syncytial virus rapid antigen detection tests (RADT) are used widely. RADT exhibited high specificity (97%) and moderate sensitivity (80%) compared with reverse-transcriptase polymerase chain reaction in 720 hospitalized children <3 years old. Older age, prolonged symptoms, and respiratory syncytial virus genotype-B infection were significantly associated with false-negative results of RADT.

Keywords: RADT; RSV; RT-PCR; RTI; Rapid antigen detection test; Respiratory syncytial virus; Respiratory tract infection; Reverse-transcriptase polymerase chain reaction.

Publication types

  • Clinical Trial
  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigens, Viral / analysis*
  • Child, Preschool
  • Chromatography, Affinity*
  • DNA, Viral / analysis
  • Female
  • Hospitalization
  • Humans
  • Infant
  • Infant, Newborn
  • Logistic Models
  • Male
  • Multivariate Analysis
  • Predictive Value of Tests
  • Prospective Studies
  • Respiratory Syncytial Virus Infections / diagnosis*
  • Respiratory Syncytial Virus Infections / virology
  • Respiratory Syncytial Virus, Human / genetics
  • Respiratory Syncytial Virus, Human / immunology
  • Respiratory Syncytial Virus, Human / isolation & purification*
  • Reverse Transcriptase Polymerase Chain Reaction
  • Sensitivity and Specificity


  • Antigens, Viral
  • DNA, Viral