Helicobacter pylori in gastric carcinogenesis: mechanisms

Gastroenterol Clin North Am. 2013 Jun;42(2):285-98. doi: 10.1016/j.gtc.2013.01.006. Epub 2013 Mar 6.


Helicobacter pylori infection induces chronic inflammation and is the strongest known risk factor for gastric cancer. The genomes of H pylori are highly diverse and therefore bacterial virulence factors play an important role in determining the outcome of H pylori infection, in combination with host responses that are augmented by environmental and dietary risk factors. It is important to gain further understanding of the pathogenesis of H pylori infection to develop more effective treatments for this common but deadly malignancy. This review focuses on the specific mechanisms used by H pylori to drive gastric carcinogenesis.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Antigens, Bacterial / genetics
  • Antigens, Bacterial / metabolism
  • Bacterial Outer Membrane Proteins / genetics
  • Bacterial Outer Membrane Proteins / metabolism*
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism
  • Carcinogenesis* / genetics
  • Carcinogenesis* / immunology
  • Carcinogenesis* / pathology
  • Helicobacter Infections / complications*
  • Helicobacter Infections / immunology
  • Helicobacter pylori*
  • Humans
  • Stomach Neoplasms / microbiology*
  • Stomach Neoplasms / pathology
  • Virulence Factors / genetics*
  • Virulence Factors / metabolism


  • Antigens, Bacterial
  • Bacterial Outer Membrane Proteins
  • Bacterial Proteins
  • VacA protein, Helicobacter pylori
  • Virulence Factors
  • cagA protein, Helicobacter pylori