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Randomized Controlled Trial
. 2013 Aug 1;115(3):325-36.
doi: 10.1152/japplphysiol.00372.2013. Epub 2013 May 2.

Beetroot Juice and Exercise: Pharmacodynamic and Dose-Response Relationships

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Randomized Controlled Trial

Beetroot Juice and Exercise: Pharmacodynamic and Dose-Response Relationships

Lee J Wylie et al. J Appl Physiol (1985). .
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Abstract

Dietary supplementation with beetroot juice (BR), containing approximately 5-8 mmol inorganic nitrate (NO3(-)), increases plasma nitrite concentration ([NO2(-)]), reduces blood pressure, and may positively influence the physiological responses to exercise. However, the dose-response relationship between the volume of BR ingested and the physiological effects invoked has not been investigated. In a balanced crossover design, 10 healthy men ingested 70, 140, or 280 ml concentrated BR (containing 4.2, 8.4, and 16.8 mmol NO3(-), respectively) or no supplement to establish the effects of BR on resting plasma [NO3(-)] and [NO2(-)] over 24 h. Subsequently, on six separate occasions, 10 subjects completed moderate-intensity and severe-intensity cycle exercise tests, 2.5 h postingestion of 70, 140, and 280 ml BR or NO3(-)-depleted BR as placebo (PL). Following acute BR ingestion, plasma [NO2(-)] increased in a dose-dependent manner, with the peak changes occurring at approximately 2-3 h. Compared with PL, 70 ml BR did not alter the physiological responses to exercise. However, 140 and 280 ml BR reduced the steady-state oxygen (O2) uptake during moderate-intensity exercise by 1.7% (P = 0.06) and 3.0% (P < 0.05), whereas time-to-task failure was extended by 14% and 12% (both P < 0.05), respectively, compared with PL. The results indicate that whereas plasma [NO2(-)] and the O2 cost of moderate-intensity exercise are altered dose dependently with NO3(-)-rich BR, there is no additional improvement in exercise tolerance after ingesting BR containing 16.8 compared with 8.4 mmol NO3(-). These findings have important implications for the use of BR to enhance cardiovascular health and exercise performance in young adults.

Keywords: O2 uptake; blood pressure; exercise economy; exercise tolerance; nitrate; nitric oxide; nitrite.

Comment in

  • To beet or not to beet?
    Burke LM. Burke LM. J Appl Physiol (1985). 2013 Aug 1;115(3):311-2. doi: 10.1152/japplphysiol.00612.2013. Epub 2013 Jun 6. J Appl Physiol (1985). 2013. PMID: 23743401 No abstract available.

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