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, 340 (6132), 562-3

Biochemistry. As Good as Chocolate

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Biochemistry. As Good as Chocolate

Krzysztof Palczewski et al. Science.

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Uncovering bias in serotonin receptor signaling
(A) Natural (serotonin/5-HT) and synthetic (ergotamine and LSD) serotonin receptor ligands have a common indole amine structure (blue) at their core. (B) Crystallographic structures of the human 5-HT1B (left) and 5-HT2B (right) receptors in a complex with ergotamine (orange). The BRIL fusion protein used to facilitate crystallization is shown as a white surface. (C) Ergotamine stabilizes distinct conformations in the two 5-HT receptors, providing a structural explanation for the biochemically observed phenomenon of biased signaling.

Comment on

  • Structural basis for molecular recognition at serotonin receptors.
    Wang C, Jiang Y, Ma J, Wu H, Wacker D, Katritch V, Han GW, Liu W, Huang XP, Vardy E, McCorvy JD, Gao X, Zhou XE, Melcher K, Zhang C, Bai F, Yang H, Yang L, Jiang H, Roth BL, Cherezov V, Stevens RC, Xu HE. Wang C, et al. Science. 2013 May 3;340(6132):610-4. doi: 10.1126/science.1232807. Epub 2013 Mar 21. Science. 2013. PMID: 23519210 Free PMC article.
  • Structural features for functional selectivity at serotonin receptors.
    Wacker D, Wang C, Katritch V, Han GW, Huang XP, Vardy E, McCorvy JD, Jiang Y, Chu M, Siu FY, Liu W, Xu HE, Cherezov V, Roth BL, Stevens RC. Wacker D, et al. Science. 2013 May 3;340(6132):615-9. doi: 10.1126/science.1232808. Epub 2013 Mar 21. Science. 2013. PMID: 23519215 Free PMC article.

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