Natural polyphenols in the management of major depression

Expert Opin Investig Drugs. 2013 Jul;22(7):863-80. doi: 10.1517/13543784.2013.794783. Epub 2013 May 6.


Introduction: Natural polyphenols, the non-essential micronutrients, found in array of plant products, are known to affect various physiological and biochemical functions in the body. Studies have shown the protective effect of these polyphenols in different neurological and mental disorders. These polyphenols modulate monoaminergic neurotransmission in the brain and thus possess antidepressant-like activity at least in animal models of depression.

Areas covered: The present review discusses the use of these natural polyphenols in the treatment of major depression. The review article discusses the antidepressant potential of some important polyphenols such as amentoflavone, apigenin, chlorogenic acid, curcumin, ferulic acid, hesperidin, rutin, quercetin, naringenin, resveratrol, ellagic acid, nobiletin and proanthocyanidins. The mechanism of action of these polyphenols in the treatment of major depression is also discussed in detail.

Expert opinion: There is an exciting prospect in the discovery of natural polyphenols as therapeutic agents in the treatment of major depression.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antidepressive Agents / isolation & purification
  • Antidepressive Agents / pharmacology
  • Antidepressive Agents / therapeutic use*
  • Behavior, Animal / drug effects
  • Biological Products / isolation & purification
  • Biological Products / pharmacology
  • Biological Products / therapeutic use*
  • Depressive Disorder, Major / drug therapy*
  • Drug Discovery
  • Humans
  • Molecular Structure
  • Polyphenols / isolation & purification
  • Polyphenols / pharmacology
  • Polyphenols / therapeutic use*


  • Antidepressive Agents
  • Biological Products
  • Polyphenols