Diabetic neuropathy part 1: overview and symmetric phenotypes

Neurol Clin. 2013 May;31(2):425-45. doi: 10.1016/j.ncl.2013.02.004. Epub 2013 Mar 15.


Diabetes is the most common cause of neuropathy in United States and neuropathies are the most common complication of diabetes mellitus, affecting up to 50% of patients with type 1 and type 2 diabetes mellitus. Symptoms usually include numbness, tingling, pain, and weakness. Dizziness with postural changes can be seen with autonomic neuropathy. Metabolic, vascular, and immune theories have been proposed for the pathogenesis of diabetic neuropathy. Axonal damage and segmental demyelination can be seen with diabetic neuropathies. Management of diabetic neuropathy should begin at the initial diagnosis of diabetes and mainly requires tight and stable glycemic control.

Publication types

  • Review

MeSH terms

  • Demyelinating Diseases / complications
  • Demyelinating Diseases / epidemiology
  • Diabetic Neuropathies / diagnosis
  • Diabetic Neuropathies / epidemiology
  • Diabetic Neuropathies / physiopathology*
  • Diabetic Neuropathies / therapy
  • Humans
  • Metabolic Diseases / complications
  • Neuritis / complications
  • Neuritis / epidemiology
  • Pain Management*
  • Phenotype*