Antiepileptic effect of dimethyl sulfoxide in a rat model of temporal lobe epilepsy

Neurosci Lett. 2013 Jun 24:546:31-5. doi: 10.1016/j.neulet.2013.04.031. Epub 2013 May 2.


Dimethyl sulfoxide (DMSO) is an amphipathic molecule widely used to solubilize water-insoluble compounds. In many studies it was reported that DMSO is capable of affecting several biological processes, thus resulting in a potential cause for the misinterpretation of experimental data. Recent papers showed that DMSO modified the brain bioelectric activity in animal models of epilepsy. In an in vivo model of temporal lobe epilepsy in the rat, we examined the effects of different doses (10%, 50% and 100%) of DMSO on the maximal dentate activation (MDA). The results show that DMSO induced a dose-dependent significant reduction of the electrically induced paroxysmal activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials / drug effects*
  • Animals
  • Anticonvulsants / administration & dosage*
  • Cerebellar Nuclei / drug effects*
  • Cerebellar Nuclei / physiopathology*
  • Dimethyl Sulfoxide / administration & dosage*
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Epilepsy, Temporal Lobe / drug therapy*
  • Humans
  • Male
  • Rats
  • Rats, Wistar
  • Treatment Outcome


  • Anticonvulsants
  • Dimethyl Sulfoxide