Isoprostanes and neuroprostanes: total synthesis, biological activity and biomarkers of oxidative stress in humans

Prostaglandins Other Lipid Mediat. 2013 Dec;107:95-102. doi: 10.1016/j.prostaglandins.2013.04.003. Epub 2013 May 2.

Abstract

Isoprostanes (IsoPs) and neuroprostanes (NeuroPs) are formed in vivo by a free radical non-enzymatic mechanism involving peroxidation of arachidonic acid (AA, C20:4 n-6) and docosahexaenoic acid (DHA, C22:6 n-3) respectively. This review summarises our research in the total synthesis of these lipid metabolites, as well as their biological activities and their utility as biomarkers of oxidative stress in humans.

Keywords: Bioactive lipids; Biomarkers; Isoprostanes; Metabolites; Neuroprostanes; PUFAs.

Publication types

  • Review

MeSH terms

  • Animals
  • Biomarkers / metabolism
  • Fatty Acids, Omega-3 / metabolism
  • Hemodynamics
  • Humans
  • Isoprostanes / biosynthesis*
  • Lipid Peroxidation
  • Neuroprostanes / biosynthesis*
  • Oxidative Stress*
  • Reperfusion Injury / metabolism

Substances

  • Biomarkers
  • Fatty Acids, Omega-3
  • Isoprostanes
  • Neuroprostanes