Pd-catalyzed Suzuki-Miyaura cross-coupling reactions between sulfamates and potassium Boc-protected aminomethyltrifluoroborates

Org Lett. 2013 May 17;15(10):2534-7. doi: 10.1021/ol401021x. Epub 2013 May 6.


Sulfamates were studied as the electrophilic partners in the palladium-catalyzed Suzuki-Miyaura cross-coupling reaction with potassium Boc-protected primary and secondary aminomethyltrifluoroborates. A broad range of substrates was successfully coupled to provide the desired products. Complex molecules containing a new carbon-carbon bond and an aminomethyl moiety could be prepared through this developed method.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Borates / chemistry*
  • Catalysis
  • Methylamines / chemistry*
  • Molecular Structure
  • Palladium / chemistry
  • Potassium / chemistry*
  • Sulfonic Acids / chemistry*


  • Borates
  • Methylamines
  • Sulfonic Acids
  • Palladium
  • sulfamic acid
  • Potassium