Whey Protein Hydrolysate Augments Tendon and Muscle Hypertrophy Independent of Resistance Exercise Contraction Mode

Scand J Med Sci Sports. 2014 Oct;24(5):788-98. doi: 10.1111/sms.12083. Epub 2013 May 7.

Abstract

In a comparative study, we investigated the effects of maximal eccentric or concentric resistance training combined with whey protein or placebo on muscle and tendon hypertrophy. 22 subjects were allocated into either a high-leucine whey protein hydrolysate + carbohydrate group (WHD) or a carbohydrate group (PLA). Subjects completed 12 weeks maximal knee extensor training with one leg using eccentric contractions and the other using concentric contractions. Before and after training cross-sectional area (CSA) of m. quadriceps and patellar tendon CSA was quantified with magnetic resonance imaging and a isometric strength test was used to assess maximal voluntary contraction (MVC) and rate of force development (RFD). Quadriceps CSA increased by 7.3 ± 1.0% (P < 0.001) in WHD and 3.4 ± 0.8% (P < 0.01) in PLA, with a greater increase in WHD compared to PLA (P < 0.01). Proximal patellar tendon CSA increased by 14.9 ± 3.1% (P < 0.001) and 8.1 ± 3.2% (P = 0.054) for WHD and PLA, respectively, with a greater increase in WHD compared to PLA (P < 0.05), with no effect of contraction mode. MVC and RFD increased by 15.6 ± 3.5% (P < 0.001) and 12-63% (P < 0.05), respectively, with no group or contraction mode effects. In conclusion, high-leucine whey protein hydrolysate augments muscle and tendon hypertrophy following 12 weeks of resistance training - irrespective of contraction mode.

Keywords: concentric training; eccentric training; isotonic; patellar tendon; rate of force development; strength training.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Dietary Carbohydrates
  • Dietary Supplements
  • Double-Blind Method
  • Electromyography
  • Exercise / physiology
  • Humans
  • Hypertrophy
  • Leucine / administration & dosage
  • Magnetic Resonance Imaging
  • Male
  • Milk Proteins*
  • Muscle Contraction / physiology
  • Muscle Strength
  • Patellar Ligament / anatomy & histology*
  • Protein Hydrolysates*
  • Quadriceps Muscle / anatomy & histology*
  • Quadriceps Muscle / physiology
  • Resistance Training / methods*
  • Whey Proteins
  • Young Adult

Substances

  • Dietary Carbohydrates
  • Milk Proteins
  • Protein Hydrolysates
  • Whey Proteins
  • Leucine