[Antioxidant and anti-inflammatory activities of Moroccan Erica arborea L]

Pathol Biol (Paris). 2013 Dec;61(6):254-8. doi: 10.1016/j.patbio.2013.03.005. Epub 2013 May 4.
[Article in French]

Abstract

Aim: The present study was carried out to evaluate the antioxidant and anti-inflammatory capacity, and acute toxicity of Moroccan Erica arborea leaves.

Methods: Antioxidant capacity was assessed by diphenyle-picryl-hydrazyl (DPPH), phosphomolybdate (PPM) and ferric reducing antioxidant power (FRAP) tests and anti-inflammatory capacity was evaluated by hind paw oedema model using carrageenan-induced inflammation in rat. The acute toxicity was evaluated using mice.

Results: Acute toxicity of ethanolic extract of E. arborea showed no sign of toxicity at dose of 5 g/kg B.W. Our extracts have important antioxidant properties. The efficient concentration of the ethanolic extract (10.22 μg/ml) required for decreasing initial DPPH concentration by 50% was comparable to that of standard solution butyl-hydroxy-toluene (BHT) (8.87 μg/ml). The administration of ethanolic extract at doses of 200 and 400mg/kg B.W. was able to prevent plantar oedema and exhibited a significant inhibition against carrageenan-induced inflammation when compared to the control group (NaCl 0.9%) but comparable to those of diclofenac (reference drug).

Conclusions: Our results show that the leaves of E. arborea may contain some bioactive compounds which are responsible for the antioxidant and anti-inflammatory activities observed here. Our finding may indicate the possibility of using the extracts of this plant to prevent the antioxidant and inflammatory processes.

Keywords: Activité anti-inflammatoire; Activité antioxydante; Acute toxicity; Anti-inflammatory activity; Antioxidant activity; Erica arborea; Ethanol extract; Extrait éthanolique; Toxicité aiguë.

Publication types

  • English Abstract

MeSH terms

  • Administration, Oral
  • Animals
  • Anti-Inflammatory Agents / pharmacology*
  • Antioxidants / pharmacology*
  • Drug Evaluation, Preclinical
  • Ericaceae* / chemistry
  • Ethanol / chemistry
  • Female
  • Male
  • Mice
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology*
  • Plant Leaves / chemistry
  • Rats
  • Rats, Wistar

Substances

  • Anti-Inflammatory Agents
  • Antioxidants
  • Plant Extracts
  • Ethanol