The role of miR-155 in regulatory T cells and rheumatoid arthritis

Clin Immunol. 2013 Jul;148(1):56-65. doi: 10.1016/j.clim.2013.03.010. Epub 2013 Mar 29.


Recently, various micro(mi)RNAs have been found deregulated in the setting of rheumatoid arthritis (RA), but their role in the pathogenesis of this disease remains a matter of debate. In the meanwhile, increasing evidence indicates a defective function of regulatory T cells (Tregs) in RA. This review discusses relevant studies addressing the function of Tregs and Cytotoxic T-Lymphocyte Antigen 4 in RA, provides recent data on the role of miRNAs for Tregs homeostasis, and focuses on the role of miR-155 in Tregs. In a final perspective section we discuss the potential impact of therapeutic miR-155 modulation in RA.

Publication types

  • Review

MeSH terms

  • Animals
  • Arthritis, Rheumatoid / genetics
  • Arthritis, Rheumatoid / immunology*
  • CTLA-4 Antigen / immunology*
  • Humans
  • MicroRNAs / immunology*
  • T-Lymphocytes, Regulatory / immunology*


  • CTLA-4 Antigen
  • MIRN155 microRNA, human
  • MicroRNAs