A perspective of comparative salivary and breast pathology. Part I: microstructural aspects, adaptations and cellular events

Eur Arch Otorhinolaryngol. 2014 Apr;271(4):647-63. doi: 10.1007/s00405-013-2488-y. Epub 2013 May 7.


This is the first part of a review comparing the pathology of salivary and mammary glands. Here, less obvious similarities and differences in functional histology and their influences on pathology are examined with emphasis on myoepithelial cells, stromal components, analogues of mucosa-associated lymphoid tissue, steroid receptors, and intraparenchymal cells of monocytic lineage. Particular cell phenotypes (oncocytic, apocrine, neuroendocrine and clear) are critically evaluated and responses to atrophy, infarction and fine-needle aspiration biopsy procedures are highlighted together with aspects of metaplasia, regeneration, ageing and microcalcification. Areas of controversy or uncertainty which may benefit from further investigations are also discussed.

Publication types

  • Review

MeSH terms

  • Adenocarcinoma / pathology*
  • Adenocarcinoma / ultrastructure
  • Adenoma / pathology*
  • Adenoma / ultrastructure
  • Breast Neoplasms / pathology*
  • Breast Neoplasms / ultrastructure
  • Female
  • Humans
  • Mammary Glands, Human / pathology*
  • Mammary Glands, Human / ultrastructure
  • Microscopy, Electron
  • Salivary Gland Neoplasms / pathology*
  • Salivary Gland Neoplasms / ultrastructure
  • Salivary Glands / pathology*
  • Salivary Glands / ultrastructure