Tricycles by a new Ugi variation and Pictet-Spengler reaction in one pot

Chemistry. 2013 Jun 17;19(25):8048-52. doi: 10.1002/chem.201300962. Epub 2013 May 6.


Subsequent mild cyclization of aromatic substrates by Pictet-Spengler condensation stereoselectively gave new tricyclic compounds. Examples are described in decent yields over two steps in one pot, and a crystal structure is also presented to support the proposed structures.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cyclization
  • Heterocyclic Compounds, 3-Ring / chemical synthesis*
  • Isoquinolines / chemical synthesis
  • Models, Molecular
  • Molecular Structure
  • Stereoisomerism


  • Heterocyclic Compounds, 3-Ring
  • Isoquinolines