Treatment of acute gouty arthritis in complex hospitalized patients with anakinra

Arthritis Care Res (Hoboken). 2013 Aug;65(8):1381-4. doi: 10.1002/acr.21989.


Objective: To report our experience with the efficacy and safety of anakinra for acute gouty arthritis in medically complex hospitalized patients.

Methods: We reviewed the hospital charts of 26 patients treated with anakinra for crystal-induced arthritis since 2007. Demographics, comorbid conditions, reason for anakinra use, response to treatment, and any adverse outcomes were recorded.

Results: Twenty-six patients received 40 courses of anakinra therapy. In 67% of patients, pain improved significantly within 24 hours, and complete resolution of signs and symptoms of gout occurred by day 5 in 72.5% of patients. Seven patients received multiple courses with no decrement in response with repeated treatments. Anakinra was well tolerated and no adverse outcomes were attributed to the medication. Only 1 patient appeared to be refractory to this form of interleukin-1 inhibition.

Conclusion: Anakinra is an effective and safe alternative treatment for acute gouty arthritis in medically complex hospitalized patients who fail or cannot undergo more conventional therapy.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Antirheumatic Agents / therapeutic use*
  • Arthritis, Gouty / complications
  • Arthritis, Gouty / drug therapy*
  • Female
  • Hospitalization*
  • Humans
  • Interleukin 1 Receptor Antagonist Protein / therapeutic use*
  • Male
  • Middle Aged
  • Retrospective Studies


  • Antirheumatic Agents
  • Interleukin 1 Receptor Antagonist Protein