Serum bisphenol-A concentration and sex hormone levels in men

Fertil Steril. 2013 Aug;100(2):478-82. doi: 10.1016/j.fertnstert.2013.04.017. Epub 2013 May 4.


Objective: To evaluate the association between serum bisphenol-A (BPA) concentration and sex hormone levels in men.

Design: Cross-sectional study.

Setting: Not applicable.

Patient(s): A total of 290 men with or without BPA exposure in the workplace.

Intervention(s): None.

Main outcome measure(s): Serum sex hormone levels.

Result(s): After adjustment for potential confounders using linear regression, increasing serum BPA concentration was statistically significantly associated with [1] decreased androstenedione levels, [2] decreased free testosterone levels, [3] decreased free androgen index, and [4] increased sex hormone-binding globulin levels. Comparison of hormone levels between workers exposed and unexposed to BPA showed similar associations.

Conclusion(s): Exposure to a high BPA level may impact sex hormone levels in men.

Keywords: BPA; Bisphenol-A; endocrine disruption; men; sex hormones.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Benzhydryl Compounds / analysis
  • Benzhydryl Compounds / blood*
  • Cross-Sectional Studies
  • Gonadal Steroid Hormones / analysis
  • Gonadal Steroid Hormones / blood*
  • Humans
  • Inhibins / blood
  • Male
  • Middle Aged
  • Osmolar Concentration
  • Phenols / analysis
  • Phenols / blood*
  • Sex Hormone-Binding Globulin / analysis
  • Young Adult


  • Benzhydryl Compounds
  • Gonadal Steroid Hormones
  • Phenols
  • Sex Hormone-Binding Globulin
  • Inhibins
  • bisphenol A