Fetomaternal immune cross-talk and its consequences for maternal and offspring's health

Nat Med. 2013 May;19(5):548-56. doi: 10.1038/nm.3160. Epub 2013 May 7.


An improved mechanistic understanding of the adaptational processes mounted during mammalian reproduction is emerging. Intricate pathways occurring at the fetomaternal interface, such as the formation of a functional synapse between invading fetal trophoblast cells, and the involvement of various maternal immune cell subsets and epigenetically modified decidual stromal cells have now been identified. These complex pathways synergistically create a tolerogenic niche in which the semiallogeneic fetus can develop. New insights into fetomaternal immune cross-talk may help us to understand the pathogenesis of pregnancy complications as well as poor postnatal health. Moreover, the effects of maternal immune adaptation to pregnancy on autoimmune disease activity are becoming increasingly evident. Thus, insights into fetomaternal immune cross-talk not only advance our understanding of pregnancy-related complications but also may be informative on how immune tolerance can be modulated in clinical settings outside the context of reproduction.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Decidua / immunology
  • Epigenesis, Genetic
  • Female
  • Fetus / immunology
  • Humans
  • Immune Tolerance / immunology
  • Maternal-Fetal Exchange / immunology*
  • Mice
  • Pregnancy
  • Pregnancy Complications
  • Reproduction / physiology*
  • Stromal Cells / cytology*
  • Trophoblasts / immunology