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. 2013 May;22(5):872-9.
doi: 10.1158/1055-9965.EPI-12-1227-T.

Sleep Disruption Among Older Men and Risk of Prostate Cancer

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Free PMC article

Sleep Disruption Among Older Men and Risk of Prostate Cancer

Lara G Sigurdardottir et al. Cancer Epidemiol Biomarkers Prev. .
Free PMC article

Abstract

Background: Although positive associations have consistently been reported between sleep disruption and breast cancer, less is known about its potential role in prostate cancer.

Methods: Within the prospective AGES-Reykjavik cohort study, we followed 2,102 men recruited in 2002-2006 until the end of 2009. Participants answered questions on sleep disruption. Information on the occurrence of prostate cancer was obtained through record linkages across the Icelandic Cancer Registry. We used Cox regression models with 95% confidence intervals (CI) to estimate HRs of prostate cancer by symptoms of sleep disruption.

Results: During follow-up, 135 men (6.4%) were diagnosed with prostate cancer. Compared with men without sleep disruption, those with problems falling and staying asleep were at significantly increased risk of prostate cancer [HR, 1.7 (95% CI, 1.0-2.9) and 2.1 (95% CI, 1.2-3.7)], respectively, with increasing sleep disruption severity. When restricted to advanced prostate cancer (≥ stage T3 or lethal disease), these associations became even stronger [HR 2.1 (95% CI, 0.7-6.2) and 3.2 (95% CI, 1.1-9.7)]. The results did not change after excluding from the analyses men who woke up during the night, indicative of nocturia, suggesting limited risk of reverse association.

Conclusions: Our data suggest that certain aspects of sleep disruption may confer an increased risk of prostate cancer and call for additional, larger studies with longer follow-up times.

Impact: Prostate cancer is one of the leading public health concerns in men; if confirmed in future studies, the association between sleep disruption and prostate cancer risk may open new avenues for prevention.

Conflict of interest statement

Disclosure of Potential Conflicts of Interest

No potential conflicts of interest were disclosed.

Figures

Figure 1
Figure 1
Categorization of sleep disruption according to combination of four questions (Q) on sleep from the AGES-Reykjavik Cohort. n=number of participants who have specified sleep problem (any other answer than “never or almost never”)
Figure 2
Figure 2
Information on TNM staging and causes of death due to prostate cancer. *All of the incident cases were identified through record linkage with the Icelandic Cancer Registry. **Information on cause-specific death was obtained through record linkage with the Statistics Iceland.

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