Plasmon based biosensor for distinguishing different peptides mutation states

Sci Rep. 2013;3:1792. doi: 10.1038/srep01792.


Periodic and reproducible gold nanocuboids with various matrix dimensions and with different inter-particle gaps were fabricated by means of top-down technique. Rhodamine 6G was used as a probe molecule to optimize the design and the fabrication of the cuboid nanostructures. The electric field distribution for the nanocuboids with varying matrix dimensions/inter-particle gap was also investigated. These SERS devices were employed as biosensors through the investigation of both myoglobin and wild/mutated peptides. The results demonstrate the probing and the screening of wild/mutated BRCA1 peptides, thus opening a path for the fabrication of simple and cheap SERS device capable of early detection of several diseases.

MeSH terms

  • BRCA1 Protein / chemistry
  • BRCA1 Protein / genetics
  • Biosensing Techniques / methods*
  • Gold / chemistry
  • Mutation
  • Myoglobin / chemistry
  • Myoglobin / genetics
  • Nanostructures / chemistry*
  • Peptides / chemistry*
  • Rhodamines / chemistry
  • Surface Plasmon Resonance / methods*


  • BRCA1 Protein
  • Myoglobin
  • Peptides
  • Rhodamines
  • rhodamine 6G
  • Gold