Assessment of glomerular filtration rate measurement with plasma sampling: a technical review

J Nucl Med Technol. 2013 Jun;41(2):67-75. doi: 10.2967/jnmt.113.121004. Epub 2013 May 8.


This article reviews available radionuclide-based techniques for glomerular filtration rate (GFR) measurement, focusing on clinical indications for GFR measurement, ideal GFR radiopharmaceutical tracer properties, and the 2 most common tracers in clinical use. Methods for full, 1-compartment, and single-sample renal clearance characterization are discussed. GFR normalization and the role of GFR measurement in chemotherapy dosing are also considered.

Keywords: GFR measurement; GFR normalization; glomerular filtration rate; radiopharmaceutical tracer; technical review.

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents / blood
  • Antineoplastic Agents / pharmacokinetics
  • Antineoplastic Agents / pharmacology
  • Blood Chemical Analysis / methods*
  • Glomerular Filtration Rate*
  • Humans
  • Kidney Function Tests / methods*
  • Radioactive Tracers


  • Antineoplastic Agents
  • Radioactive Tracers