RIGOR guidelines: escalating STAIR and STEPS for effective translational research

Transl Stroke Res. 2013 Jun;4(3):279-85. doi: 10.1007/s12975-012-0209-2. Epub 2012 Sep 5.


Stroke continues to be a serious and significant health problem in the USA and worldwide. This article will emphasize the need for good laboratory practices, transparent scientific reporting, and the use of translational research models representative of the disease state to develop effective treatments. This will allow for the testing and development of new innovative strategies so that efficacious therapies can be developed to treat ischemic and hemorrhagic stroke. This article recommends guidelines for effective translational research, most importantly, the need for study blinding, study group randomization, power analysis, accurate statistical analysis, and a conflict of interest statement. Additional guidelines to ensure reproducibility of results and confirmation of efficacy in multiple species are discussed.

Keywords: Brain; Clinical Trial; Hemorrhage; ICH; NIHSS; RIGOR; SAH; STAIR; STEPS; Stroke; Translational.

Publication types

  • Historical Article
  • Research Support, N.I.H., Extramural

MeSH terms

  • Aged
  • Clinical Laboratory Techniques / standards
  • Disclosure
  • Female
  • History, 16th Century
  • History, 17th Century
  • History, 18th Century
  • History, 19th Century
  • History, 20th Century
  • History, Ancient
  • Humans
  • Male
  • Practice Guidelines as Topic*
  • Randomized Controlled Trials as Topic
  • Research Design
  • Stem Cell Transplantation / methods
  • Stroke / history
  • Stroke / therapy*
  • Translational Medical Research*