Abstract
Two new phenolic compounds 4-(4'-hydroxybenzyl) phenyl glucoside (gastrodin B, 1) and 1'-hydroxymethyl-phenyl 4-hydroxy-3-(4″-hydroxybenzyl) benzyl ether (gastrol B, 2) were isolated from the rhizomes of Gastrodia elata. Their structures were elucidated on the basis of spectroscopic data and chemical reaction. All compounds exhibited potent neuroprotective activity against H2O2-induced PC12 cell damage.
MeSH terms
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Animals
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology*
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Gastrodia / chemistry*
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Glucosides / chemistry
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Glucosides / isolation & purification*
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Glucosides / pharmacology*
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Hydrogen Peroxide / pharmacology
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Neuroprotective Agents / chemistry
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Neuroprotective Agents / isolation & purification*
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Neuroprotective Agents / pharmacology*
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Nuclear Magnetic Resonance, Biomolecular
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PC12 Cells
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Phenols / chemistry
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Phenols / isolation & purification*
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Phenols / pharmacology*
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Phenyl Ethers / chemistry
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Phenyl Ethers / isolation & purification*
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Phenyl Ethers / pharmacology*
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Rats
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Rhizome / chemistry
Substances
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1'-hydroxymethyl-phenyl 4-hydroxy-3-(4'-hydroxybenzyl) benzyl ether
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4-(4'-hydroxybenzyl)phenyl glucoside
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Drugs, Chinese Herbal
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Glucosides
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Neuroprotective Agents
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Phenols
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Phenyl Ethers
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Hydrogen Peroxide