Fabrication of novel silicone capsules with tunable mechanical properties by microfluidic techniques

ACS Appl Mater Interfaces. 2013 Jun 12;5(11):5247-52. doi: 10.1021/am4010896. Epub 2013 May 17.


A novel approach for the synthesis of silicone capsules using double W/O/W emulsions as templates is introduced. The low viscosity of the silicone precursors enables the use of microfluidic techniques to accurately control the size and morphology of the double emulsion droplets, which after cross-linking result in the desired monodisperse silicone capsules. Their shell thickness can be finely tuned, which in turn allows control over their permeability and mechanical properties; the latter are particularly important in a variety of practical applications where the capsules are subjected to large external forces. The potential of these capsules for controlled release is also demonstrated using a model hydrophilic substance.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Capsules
  • Cosmetics / chemistry
  • Dimethylpolysiloxanes / chemistry
  • Drug Delivery Systems / methods*
  • Elasticity
  • Emulsions / chemistry*
  • Humans
  • Hydrophobic and Hydrophilic Interactions
  • Microfluidics / methods*
  • Microscopy, Electron, Scanning
  • Models, Chemical
  • Nylons / chemistry
  • Silicones / chemistry*
  • beta-Glucosidase / chemistry


  • Capsules
  • Cosmetics
  • Dimethylpolysiloxanes
  • Emulsions
  • Nylons
  • Silicones
  • poly(dimethylsiloxane)-polyamide copolymer
  • beta-Glucosidase