Objective: To explore the effects of lipoprotein(a) (Lp(a)) and fibrinogen (Fib) in senior patients with coronary heart disease (CHD) and examine the relationship of Lp(a) and Fib.
Methods: Based upon the results of coronary artery angiography (CAG), 784 subjects aged over 65 years were divided into control (n = 116) group, one-vessel (n = 106) group, two-vessel (n = 120) and three-vessel (n = 442) groups. And the levels of Lp(a) and Fib were measured.
Results: (1) With increasing number of involved branches, the level of Lp(a) gradually rose in male group ((0.22 ± 0.16), (0.28 ± 0.23), (0.32 ± 0.19), (0.34 ± 0.21) g/L; F = 9.22, P < 0.01); (2) whether for males or females, with increasing number of involved branches, the levels of Fib gradually rose in male group ((3.24 ± 0.82), (3.41 ± 0.82), (3.45 ± 0.89), (3.61 ± 0.90) g/L; F = 3.09, P < 0.05) and in female group ((3.58 ± 0.97), (3.69 ± 1.20), (3.77 ± 0.88), (4.09 ± 1.05) g/L; F = 4.34, P < 0.01); (3) the level of Lp(a) had a positive correlation with Fib in male group (r = 0.15, P < 0.01); (4) multi-Logistic regression analysis showed that Lp(a) and Fib were influencing factors of CHD (OR = 0.31, 1.32, both P < 0.05).
Conclusion: There are significant correlations between Lp(a), Fib and the severity of CHD in senior male patients.