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Editorial
. 2013 Aug 24;27(13):2003-17.
doi: 10.1097/QAD.0b013e328362ba67.

The Burden of HIV: Insights From the Global Burden of Disease Study 2010

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Free PMC article
Editorial

The Burden of HIV: Insights From the Global Burden of Disease Study 2010

Katrina F Ortblad et al. AIDS. .
Free PMC article

Abstract

Objectives: To evaluate the global and country-level burden of HIV/AIDS relative to 291 other causes of disease burden from 1980 to 2010 using the Global Burden of Disease Study 2010 (GBD 2010) as the vehicle for exploration.

Methods: HIV/AIDS burden estimates were derived elsewhere as a part of GBD 2010, a comprehensive assessment of the magnitude of 291 diseases and injuries from 1990 to 2010 for 187 countries. In GBD 2010, disability-adjusted life years (DALYs) are used as the measurement of disease burden. DALY estimates for HIV/AIDS come from UNAIDS' 2012 prevalence and mortality estimates, GBD 2010 disability weights and mortality estimates derived from quality vital registration data.

Results: Despite recent declines in global HIV/AIDS mortality, HIV/AIDS was still the fifth leading cause of global DALYs in 2010. The distribution of HIV/AIDS burden is not equal across demographics and regions. In 2010, HIV/AIDS was ranked as the leading DALY cause for ages 30-44 years in both sexes and for 21 countries that fall into four distinctive blocks: Eastern and Southern Africa, Central Africa, the Caribbean and Thailand. Although a majority of the DALYs caused by HIV/AIDS are in high-burden countries, 20% of the global HIV/AIDS burden in 2010 was in countries where HIV/AIDS did not make the top 10 leading causes of burden.

Conclusion: In the midst of a global economic recession, tracking the magnitude of the HIV/AIDS epidemic and its importance relative to other diseases and injuries is critical to effectively allocating limited resources and maintaining funding for effective HIV/AIDS interventions and treatments.

Figures

Fig. 1
Fig. 1
Global HIV/AIDS mortality, 1980–2010.
Fig. 2
Fig. 2
Global ranks for top 25 causes of disability-adjusted life years, 1990–2010.
Fig. 3
Fig. 3
Global HIV/AIDS disability-adjusted life year rank by age and sex, 2010.
Fig. 4
Fig. 4
HIV/AIDS disability-adjusted life year rank by country, 2010.
Fig. 5
Fig. 5
Summation of country-level HIV/AIDS disability-adjusted life years by rank, 2010.
Fig. 6
Fig. 6
Southern sub-Saharan Africa and South Asia ranks for top 25 causes of disability-adjusted life years, 1990–2010. (a) Southern sub-Saharan Africa; (b) South Asia.

Comment in

  • Putting the burden of HIV in context.
    Gregson S, Hallett TB, Stover J, Ghys PD. Gregson S, et al. AIDS. 2013 Aug 24;27(13):2161-2. doi: 10.1097/QAD.0b013e3283638641. AIDS. 2013. PMID: 24384593 No abstract available.

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