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. 2013;3:1818.
doi: 10.1038/srep01818.

Relationship Between Low Free Testosterone Levels and Loss of Muscle Mass

Free PMC article

Relationship Between Low Free Testosterone Levels and Loss of Muscle Mass

Atsumu Yuki et al. Sci Rep. .
Free PMC article


We assessed longitudinal relationships between baseline testosterone and muscle mass changes in Japanese men. Data were collected from community-dwelling 957 adult men who participated in a longitudinal study of ageing biennially from 1997-2010. Appendicular muscle mass (AMM) was measured with dual-energy X-ray absorptiometry at baseline and follow-up examinations. The cut-off point of sarcopenia was defined as a skeletal muscle index (AMM/height(2)) < 6.87 kg/m(2). Total testosterone (TT) and free testosterone (FT) were measured with a radioimmunoassay. The calculated FT (cFT) was determined with a formula using albumin, TT, and sex hormone-binding globulin levels. We analyzed 4,187 or 2,010 cumulative data points using generalized estimating equations. Low TT was not associated with sarcopenia. Low cFT (odds ratio = 2.14, 95% confidence interval: 1.06-4.33) and FT (odds ratio = 1.83, 95% confidence interval: 1.04-3.22) were associated with sarcopenia. Low FT may be a predictor of risk for muscle loss in Japanese men.

Conflict of interest statement

The authors declare no competing financial interests.

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