Cisplatin (cisdiamminedichloroplatinum) for treatment of transitional cell carcinoma of the urinary bladder or urethra. A retrospective study of 15 dogs

J Vet Intern Med. May-Jun 1990;4(3):148-52. doi: 10.1111/j.1939-1676.1990.tb00888.x.

Abstract

The records of 15 sequential cases of transitional cell carcinoma of the urinary bladder or urethra in dogs were examined to determine the results of treatment with cisplatin (cisdiamminedichloroplatinum) and to record and assess toxicities. All dogs had measurable disease and were considered eligible for evaluation of toxicity following one cisplatin treatment. Three dogs were eliminated from evaluation of efficacy because of acute toxicities. Of the 12 remaining dogs that received two or more cisplatin treatments, evaluations at the end of the second month of treatment revealed no complete responses; however, three dogs showed partial responses and six dogs maintained stable disease. Three dogs had tumor progression. The median survival time for these 12 dogs was 180 days (mean, 220 days; range, 36 to 589 days). Three dogs were azotemic before treatment. Two of these dogs showed improvement in renal function following therapy. Six of the other twelve dogs developed increases in serum creatinine during therapy. The objective and subjective improvements of some dogs to cisplatin chemotherapy suggest that this agent is active in selected dogs with transitional cell carcinomas of the urinary tract.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Carcinoma, Transitional Cell / drug therapy
  • Carcinoma, Transitional Cell / veterinary*
  • Cisplatin / adverse effects
  • Cisplatin / therapeutic use*
  • Creatinine / blood
  • Diarrhea / chemically induced
  • Diarrhea / veterinary
  • Dog Diseases / drug therapy*
  • Dogs
  • Female
  • Male
  • Retrospective Studies
  • Uremia / chemically induced
  • Uremia / veterinary
  • Urethral Neoplasms / drug therapy
  • Urethral Neoplasms / veterinary*
  • Urinary Bladder Neoplasms / drug therapy
  • Urinary Bladder Neoplasms / veterinary*
  • Vomiting / chemically induced
  • Vomiting / veterinary

Substances

  • Creatinine
  • Cisplatin