RAN translation: fragile X in the running

Neuron. 2013 May 8;78(3):405-8. doi: 10.1016/j.neuron.2013.04.034.

Abstract

In this issue of Neuron, Todd et al. (2013) reveal that noncanonical repeat associated non-AUG (RAN) translation occurs on nonexpanded (CGG)30-50 and premutation (CGG)59-160 repeats, associated with the FMR1 gene, suggesting that the polyglycine and polyalanine products might have natural and pathogenic roles.

Publication types

  • Comment