The cell-autonomous role of excitatory synaptic transmission in the regulation of neuronal structure and function

Neuron. 2013 May 8;78(3):433-9. doi: 10.1016/j.neuron.2013.02.030.


The cell-autonomous role of synaptic transmission in the regulation of neuronal structural and electrical properties is unclear. We have now employed a genetic approach to eliminate glutamatergic synaptic transmission onto individual CA1 pyramidal neurons in a mosaic fashion in vivo. Surprisingly, while electrical properties are profoundly affected in these neurons, as well as inhibitory synaptic transmission, we found little perturbation of neuronal morphology, demonstrating a functional segregation of excitatory synaptic transmission from neuronal morphological development.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural

MeSH terms

  • Action Potentials / genetics
  • Action Potentials / physiology
  • Animals
  • CA1 Region, Hippocampal / cytology
  • CA1 Region, Hippocampal / physiology*
  • Cell Shape / genetics
  • Cell Shape / physiology
  • Excitatory Postsynaptic Potentials / genetics
  • Excitatory Postsynaptic Potentials / physiology*
  • Glutamic Acid / physiology*
  • Mice
  • Patch-Clamp Techniques
  • Pyramidal Cells / cytology
  • Pyramidal Cells / physiology*
  • Synapses / genetics
  • Synapses / physiology*
  • Synaptic Transmission / genetics
  • Synaptic Transmission / physiology*
  • gamma-Aminobutyric Acid / physiology


  • Glutamic Acid
  • gamma-Aminobutyric Acid