Abstract
Probestin is a potent aminopeptidase N (APN) inhibitor originally isolated from the bacterial culture broth. Here, we report probestin synthesis by solid phase peptide synthesis (SPPS) method and evaluated its activity to inhibit angiogenesis using a chicken embryo chorioallantoic membrane (CAM) assay and a CAM tumor xenograft model. Results from these studies demonstrate that probestin inhibits the angiogenic activity and tumor growth.
Copyright © 2013 Elsevier Ltd. All rights reserved.
Publication types
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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Angiogenesis Inhibitors / chemical synthesis*
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Angiogenesis Inhibitors / chemistry
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Angiogenesis Inhibitors / pharmacology*
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Animals
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Breast Neoplasms / blood supply
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Breast Neoplasms / drug therapy
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CD13 Antigens / antagonists & inhibitors
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Cell Line, Tumor
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Chick Embryo
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Chorioallantoic Membrane / blood supply
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Female
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Humans
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Mice, Inbred BALB C
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Neovascularization, Physiologic / drug effects
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Oligopeptides / chemical synthesis*
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Oligopeptides / chemistry
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Oligopeptides / pharmacology*
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Solid-Phase Synthesis Techniques / methods
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Xenograft Model Antitumor Assays
Substances
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Angiogenesis Inhibitors
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Oligopeptides
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probestin
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CD13 Antigens