Penicillin-induced epileptiform activity elevates focal brain temperature in anesthetized rats

Neurosci Res. 2013 Aug;76(4):257-60. doi: 10.1016/j.neures.2013.05.001. Epub 2013 May 9.


To elucidate a relationship between changes in focal brain temperature and severity of abnormal brain activity, epileptiform discharges and behavioral seizures were induced by Penicillin G in anesthetized rats, and focal brain-temperature was measured. Penicillin G was injected into the right primary sensorimotor cortex (400IU/μl). After the injection, epileptiform discharges induced a temperature increase gradually by 0.65±0.24°C. Moreover, when behavioral seizures were induced by reducing the anesthesia level, the temperature was raised by 0.26±0.22°C. These results suggest that elevation of the focal brain temperature is associated with the severity of epileptic activity.

Keywords: Behavioral seizures; Epileptiform discharges; Focal brain temperature; Penicillin G; Sensorimotor cortex; Thermocouple.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain / physiopathology*
  • Cerebral Cortex / physiopathology*
  • Disease Models, Animal
  • Electroencephalography / methods
  • Epilepsy / chemically induced
  • Epilepsy / physiopathology*
  • Male
  • Penicillins / toxicity*
  • Rats
  • Rats, Wistar
  • Temperature


  • Penicillins