Chlorhexidine: uses and adverse reactions

Dermatitis. 2013 May-Jun;24(3):112-8. doi: 10.1097/DER.0b013e3182905561.

Abstract

Chlorhexidine is increasingly being used not only as an antiseptic to prevent hospital infections and an adjuvant in oral hygiene but also as a preservative in personal care products. As exposure to the agent becomes more widespread, reports of adverse reactions to it are increasing. Complications range from mild irritant contact dermatitis to life-threatening anaphylaxis. Allergic contact dermatitis in some cases precedes anaphylaxis. It is imperative that physicians be aware of the many possible sources of contact with this antiseptic and be alert to recognize the potentially debilitating and catastrophic reactions that may occur because of chlorhexidine sensitization.

Publication types

  • Review

MeSH terms

  • Anaphylaxis / chemically induced*
  • Anaphylaxis / prevention & control
  • Anti-Infective Agents, Local / adverse effects*
  • Anti-Infective Agents, Local / therapeutic use*
  • Chlorhexidine / adverse effects*
  • Chlorhexidine / therapeutic use*
  • Dermatitis, Allergic Contact / etiology*
  • Dermatitis, Allergic Contact / prevention & control
  • Humans

Substances

  • Anti-Infective Agents, Local
  • Chlorhexidine