Two Cases of Myeloproliferative Neoplasm With a Concurrent JAK2 (V617F) Mutation and BCR/ABL Translocation Without Chronic Myelogenous Leukemia Phenotype Acquisition During Hydroxyurea Treatment

Ann Lab Med. 2013 May;33(3):229-32. doi: 10.3343/alm.2013.33.3.229. Epub 2013 Apr 17.

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Adult
  • Alleles
  • Fusion Proteins, bcr-abl / genetics*
  • Heterozygote
  • Humans
  • Hydroxyurea / therapeutic use*
  • Janus Kinase 2 / genetics*
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / diagnosis
  • Leukocytes, Mononuclear / pathology
  • Leukocytosis / diagnosis
  • Male
  • Middle Aged
  • Mutation
  • Myeloproliferative Disorders / drug therapy
  • Myeloproliferative Disorders / genetics*
  • Phenotype
  • Splenomegaly / diagnosis
  • Thrombocytosis / diagnosis
  • Translocation, Genetic

Substances

  • Fusion Proteins, bcr-abl
  • Janus Kinase 2
  • Hydroxyurea