Effects of an acute bout of resistance exercise on fiber-type specific to GLUT4 and IGF-1R expression

Appl Physiol Nutr Metab. 2013 May;38(5):581-6. doi: 10.1139/apnm-2012-0301. Epub 2013 Feb 27.


The effects of resistance exercise on fiber-type-specific expression of insulin-like growth factor I receptor (IGF-1R) and glucose transporter 4 (GLUT4) was determined in 6 healthy males. The expression of both genes increased in Type I fibers (p < 0.05), but only GLUT4 increased (p < 0.05) in Type II fibers. These data demonstrates that an acute bout of resistance exercise can up-regulate mechanisms of glucose uptake in slow and fast-twitch fibers, but the IGF signaling axis may not be as effective in fast-twitch fibers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Dietary Fiber
  • Exercise
  • Glucose Transporter Type 4*
  • Humans
  • Insulin-Like Growth Factor I* / metabolism
  • Muscle Fibers, Fast-Twitch / metabolism
  • Signal Transduction


  • Dietary Fiber
  • Glucose Transporter Type 4
  • Insulin-Like Growth Factor I