Signaling networks of Rho GTPases in cell motility

Cell Signal. 2013 Oct;25(10):1955-61. doi: 10.1016/j.cellsig.2013.04.009. Epub 2013 May 11.


The last decades have witnessed an exponential increase in our knowledge of Rho GTPase signaling network which further highlighted the cross talk between these proteins and the complexity of their signaling pathways. In this review, we summarize the upstream and downstream players from Rho GTPases that are mainly involved in actin polymerization leading to cell motility and potentially playing a role in cancer cell metastasis.

Keywords: Actin; Cancer; Motility; PI3K; Rho GTPases.

Publication types

  • Review

MeSH terms

  • Actins / chemistry
  • Actins / metabolism*
  • Cell Movement / genetics*
  • Humans
  • Neoplasms / genetics*
  • Neoplasms / metabolism
  • Neoplasms / pathology
  • Signal Transduction / genetics
  • rho GTP-Binding Proteins / genetics*
  • rho GTP-Binding Proteins / metabolism


  • Actins
  • rho GTP-Binding Proteins