Understanding the Interplay Between the Proteasome Pathway and Autophagy in Response to Dual PI3K/mTOR Inhibition in Myeloma Cells Is Essential for Their Effective Clinical Application

Leukemia. 2013 Dec;27(12):2397-403. doi: 10.1038/leu.2013.150. Epub 2013 May 14.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Autophagy*
  • Humans
  • Multiple Myeloma / enzymology
  • Multiple Myeloma / metabolism
  • Multiple Myeloma / pathology*
  • Phosphoinositide-3 Kinase Inhibitors*
  • Proteasome Endopeptidase Complex / metabolism*
  • TOR Serine-Threonine Kinases / antagonists & inhibitors*

Substances

  • Phosphoinositide-3 Kinase Inhibitors
  • MTOR protein, human
  • TOR Serine-Threonine Kinases
  • Proteasome Endopeptidase Complex