Abstract
Novel silicate nanoplatelets that induce osteogenic differentiation of human mesenchymal stem cells (hMSCs) in the absence of any osteoinductive factor are reported. The presence of the silicate triggers a set of events that follows the temporal pattern of osteogenic differentiation. These findings underscore the potential applications of these silicate nanoplatelets in designing bioactive scaffolds for musculoskeletal tissue engineering.
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Cell Differentiation
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Cell Survival / drug effects
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Cells, Cultured
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Humans
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Mesenchymal Stem Cells / cytology*
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Mesenchymal Stem Cells / metabolism
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Nanostructures / chemistry*
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Nanostructures / toxicity
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Osteogenesis
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Reactive Nitrogen Species / metabolism
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Reactive Oxygen Species / metabolism
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Silicates / chemistry*
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Tissue Engineering
Substances
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Reactive Nitrogen Species
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Reactive Oxygen Species
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Silicates