Bioactive silicate nanoplatelets for osteogenic differentiation of human mesenchymal stem cells

Adv Mater. 2013 Jun 25;25(24):3329-36. doi: 10.1002/adma.201300584. Epub 2013 May 13.

Abstract

Novel silicate nanoplatelets that induce osteogenic differentiation of human mesenchymal stem cells (hMSCs) in the absence of any osteoinductive factor are reported. The presence of the silicate triggers a set of events that follows the temporal pattern of osteogenic differentiation. These findings underscore the potential applications of these silicate nanoplatelets in designing bioactive scaffolds for musculoskeletal tissue engineering.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Cell Differentiation
  • Cell Survival / drug effects
  • Cells, Cultured
  • Humans
  • Mesenchymal Stem Cells / cytology*
  • Mesenchymal Stem Cells / metabolism
  • Nanostructures / chemistry*
  • Nanostructures / toxicity
  • Osteogenesis
  • Reactive Nitrogen Species / metabolism
  • Reactive Oxygen Species / metabolism
  • Silicates / chemistry*
  • Tissue Engineering

Substances

  • Reactive Nitrogen Species
  • Reactive Oxygen Species
  • Silicates