Breast cancer is one of the leading causes of death in women. Cancer epidemiologists have stated that breast cancer is the most common cancer in women in developed countries, Nepal is not an exception. Breast cancer is the second most common cancer in women of Nepal after cervical cancer. A Qualitative phenomenological study was done to explore the psychological impact of women with mastectomy after diagnosis of breast cancer. In-depth study was done with ten women age ranging from 36 to 50 years. Ten women were interviewed which was recorded, and verbatim were transcribed before taking next interview. The interviews were analyzed in three stages as stated by Miles and Hubermans. Findings revealed that respondents expressed the fear of death, emotional impact of the loss of breast disfigurement, loss of femininity, fear of recurrence of disease, and concern about their family. Breast cancer and mastectomy have impact on women psychosocial state. They develop stress due to loss of body part, loss of femininity, fear of recurrence of disease, fear of cost and prolong treatment protocol.