Abstract
Thymus-reticular epithelial cells (TE-cells) were grown in a cell culture devoid of any lymphocytic elements. These cells were able to induce T-cell differentiation in spleen cells from T-dificient mice as expressed by con-A responsiveness and GvH reactivity. It was also shown that xenogeneic rat TE cells were as effective in the induction of T-cell differentiation in vitro as syngeneic TE cells. This system is therefore ideal for the study of T-cell development.
MeSH terms
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Animals
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Cell Differentiation*
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Cells, Cultured
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Concanavalin A
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DNA / biosynthesis
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Epithelial Cells*
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Epithelium / immunology*
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Epithelium / ultrastructure
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Female
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Graft vs Host Reaction
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Lymphocyte Activation
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Mice
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Mice, Inbred C57BL
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Microscopy, Electron
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Radiation Chimera
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Rats
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Rats, Inbred Lew
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Species Specificity
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Spleen / cytology
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T-Lymphocytes / immunology*
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T-Lymphocytes / transplantation
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Thymectomy
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Thymidine / metabolism
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Thymus Gland / cytology*
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Thymus Gland / immunology
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Transplantation, Homologous
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Tritium
Substances
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Tritium
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Concanavalin A
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DNA
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Thymidine