Spectrins: a structural platform for stabilization and activation of membrane channels, receptors and transporters

Biochim Biophys Acta. 2014 Feb;1838(2):620-34. doi: 10.1016/j.bbamem.2013.05.002. Epub 2013 May 11.


This review focuses on structure and functions of spectrin as a major component of the membrane skeleton. Recent advances on spectrin function as an interface for signal transduction mediation and a number of data concerning interaction of spectrin with membrane channels, adhesion molecules, receptors and transporters draw a picture of multifaceted protein. Here, we attempted to show the current depiction of multitask role of spectrin in cell physiology. This article is part of a Special Issue entitled: Reciprocal influences between cell cytoskeleton and membrane channels, receptors and transporters. Guest Editor: Jean Claude Hervé.

Keywords: (N-methyl-d-aspartate) receptor; (after Landsteiner and Wiener) blood group antigen glycoprotein; 3′-5′-cyclic adenosine monophosphate; ABD; AE1; Anion exchange protein 1 and Band 3 anion transport protein; Arp1; CD47; CH1; CHL1; DRM; EAAT4; EF-hand domain; ERM; EVL; Enabled/VASP (vasodilator-stimulated phosphoprotein)-like protein; FA; Fanconi anemia; GABA; GLUT1; GPB; GPC; LW; Lu/B-CAM; Lutheran blood group and basal cell adhesion molecule; MPP1; NMDA; Neural cell adhesion molecule L1-like protein; Neuron-Glia Cell Adhesion Molecule)-Related Cell Adhesion Molecule; Neuronal cell adhesion molecule; NgCAM; NrCAM; PH; PIP2; PKA; PKCβ(2); PSDs; Phosphatidylinositol 4,5-bisphosphate; Plasma membrane domain; Protein Kinase-A; Rh; Rh-associated glycoprotein; RhAG; Rhesus protein; SCA5; SH3; SRC homology 3 domain; Spectrin; Spectrin-based membrane skeleton; Spinocerebellar Ataxia Type 5; T cell receptor; TCR; TGFβ; Transforming growth factor beta; VASP; VGSC; Vasodilator-stimulated phosphoprotein; actin binding domain; actin-related protein 1; cAMP; calcium-binding domain; calponin homology domain; detergent-resistant membrane; excitatory amino acid transporters 4; ezrin–radixin–moesin family; glucose transporter protein 1; glycophorin B; glycophorin C; integrin-associated protein; membrane protein, palmitoylated 1; perforated postsynaptic densities; pleckstrin homology domain; protein kinase C β2; voltage-gated sodium channels; γ-Aminobutyric acid.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Ion Channels / chemistry
  • Ion Channels / metabolism*
  • Membrane Transport Proteins / chemistry
  • Membrane Transport Proteins / metabolism*
  • Receptors, Cell Surface / chemistry
  • Receptors, Cell Surface / metabolism*
  • Spectrin / metabolism*


  • Ion Channels
  • Membrane Transport Proteins
  • Receptors, Cell Surface
  • Spectrin