Scaling the MAPK signaling threshold during CNS patterning

Dev Cell. 2013 May 13;25(3):221-2. doi: 10.1016/j.devcel.2013.04.014.


Morphogenic gradients originating from signaling centers along the CNS developmental axes contribute to CNS patterning. Reporting in this issue of Developmental Cell, Lanctot et al. (2013) show that the Nde1-Lis1 complex interacts with Brap, a mitogen-activated protein kinase pathway negative regulator, to facilitate position-dependent modulation of neural progenitor fate and CNS patterning.

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